| Trans Num | Date | Details |
| 2020.27 | 2020-08-17 | Pittsburgh Pirates trade Edwin Encarnacion and LAD 2021 #4 to the Los Angeles Angels for Will Harris. |
| 2018.29 | 2018-11-28 | Pittsburgh trades Andrew McCutchen to Toronto for Edwin Encarnacion, C.C. Sabathia, and Dexter Fowler. |