| Trans Num | Date | Details |
| 2010.45 | 2010-12-29 | Tampa Bay trades Jon Jay to St. Louis for Wil Nieves and STL 2012 #1. |
| 2010.32 | 2010-12-16 | Pittsburgh trades Adrian Gonzalez, Andy LaRoche, Jon Jay, and PIT 2011 #5 to Tampa Bay for Yonder Alonso, Lance Berkman, Jeff Niemann, TBR 2011 #2, and TBR 2011 #3. |
| 2010.3 | 2010-12-16 | Pittsburgh trades Brett Myers to St. Louis for Jon Jay and STL 2011 #1. |