| Trans Num | Date | Details |
| 2018.21 | 2018-03-20 | Pittsburgh trades Blake Snell and Jung Ho Kang to Boston for Joe Musgrove and Steven Cishek. |
| 2018.16 | 2018-02-23 | Pittsburgh trades Joey Votto and Michael Fulmer to Tampa Bay for Corey Dickerson, Anthony Rendon, and Blake Snell. |